| Pathway Id | ko03420 |
| Class & Sub-Class | Class: Genetic Information Processing Sub-Class: Replication and repair |
| Description | Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds; environmental carcinogens; and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP); Cockayne syndrome (CS); and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes; uvrAB complex). The following steps of GGR-NER and TCR-NER are similar. Source: KEGG Database |
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